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Comparison of Osteoporosis Treatment

Brand Active Ingredient Increases BMD? Physiological Function Prerequisite Side Effects
EZorb® Calcium Aspartate Anhydrous Yes Stimulates osteoblasts* to create more new bone mass. None No known side effects.
Fosamax® Bisphosphonates No Retains old bone mass by killing osteoclasts.** Calcium Blood in stool and urine, fatigue, stomach ulcers, nausea, hair loss, headache, blurred vision, heartburn.
Actonel® Bisphosphonates No Retains old bone mass by killing osteoclasts. Calcium Pain swallowing, back pain, ulcers in stomach esophagus, joint pain, constipation, weight gain, hair loss.
Boniva® Bisphosphonates No Retains old bone mass by killing osteoclasts. Calcium Severe pain in bone, joint and muscle, very bad heartburn, difficulty swallowing, diarrhea, chest pain.
Evista® Raloxifene No Acts as an estrogen. Calcium Blood clots in the veins, hot flashes, cramps, swelling, sleep difficulty, depression, speech problems.
Forteo® Teriparatide Yes Acts as parathyroid hormone. Calcium Causing bone cancer in lab rats, dizziness, leg cramps, chest pain, vomiting, constipation, sluggishness.
Prolia® Denosumab No Retains old bone mass by slowing down osteoclasts development. Calcium Joint and muscle pain in the arms and legs, dead jaw bones, low blood calcium level, hypersensitivity allergy reactions.

Healthy bones are constantly rebuilding themselves. Old bone mass is broken down and removed by osteoclasts and new bone mass is formed by osteoblasts.

* Osteoblasts are cells that are responsible for creating new bone mass.
** Osteoclasts are cells associated with bone resorption.