Comparison of Osteoporosis Treatment
|Brand||Active Ingredient||Increases BMD?||Physiological Function||Prerequisite||Side Effects|
|EZorb®||Calcium Aspartate Anhydrous||Yes||Stimulates osteoblasts* to create more new bone mass.||None||No known side effects.|
|Bisphosphonates||No||Retains old bone mass by killing osteoclasts.**||Calcium/Vit.D||Blood in stool and urine, fatigue, stomach ulcers, nausea, hair loss, headache, blurred vision, heartburn,joint pain, constipation, weight gain, diarrhea, chest pain.|
|Evista®||Raloxifene||No||Acts as an estrogen.||Calcium/Vit.D||Blood clots in the veins, hot flashes, cramps, swelling, sleep difficulty, depression, speech problems.|
|Yes||Acts as parathyroid hormone.||Calcium/Vit.D||Causing bone cancer in lab rats, dizziness, leg cramps, chest pain, vomiting, constipation, sluggishness.|
|Prolia®||Denosumab||No||Retains old bone mass by slowing down osteoclasts development.||Calcium/Vit.D||Joint and muscle pain in the arms and legs, dead jaw bones, low blood calcium level, hypersensitivity allergy reactions.|
Healthy bones are constantly rebuilding themselves. Old bone mass is broken down and removed by osteoclasts and new bone mass is formed by osteoblasts.
* Osteoblasts are cells that are responsible for creating new bone mass.
** Osteoclasts are cells associated with bone resorption.