Makers of EZorb and Marvlix



Spine. 2003 Jul 15;28(14):1534-9


A biomechanical analysis of intravertebral pressures during vertebroplasty of cadaveric spines with and without simulated metastases.


Reidy D, Ahn H, Mousavi P, Finkelstein J, Whyne CM.



A biomechanical cadaveric study of thoracic and lumbar vertebrae with simulated metastases quantifying intravertebral pressures during transpedicular vertebroplasty.



To compare intravertebral pressures during percutaneous vertebroplasty in vertebrae with and without simulated lytic metastases.



Percutaneous vertebroplasty is designed to provide stability to vertebrae weakened by osteoporosis or metastatic disease. The complication rate is higher when the procedure is used for the treatment of lytic vertebral lesions. The major complications reported are radiculopathy, spinal cord compression, and embolic phenomena.



Ten fresh-frozen cadaveric vertebrae were tested intact (7 lumbar, 3 thoracic) and 7 were tested with simulated lytic defects (4 lumbar, 3 thoracic). Defects were created by replacing a core of cancellous bone with soft tumor tissue in the center of the vertebral body. Simplex P (Howmedica Osteonics, Mahwah, NJ) cement was injected into each vertebra through a unipedicular approach at a constant rate of 3 mL per minute. Cement volume, injection force, and intravertebral pressures at the posterior vertebral body wall were recorded. Following the procedure, the vertebrae were sectioned to visualize cement and tumor disbursement.



There was no significant difference between the two groups for age, size, trabecular density, and cement volume. Vertebrae with simulated metastases generated an average maximum pressure of 39.66 kPa during cement injection versus 6.83 kPa in intact vertebrae (P < 0.05). Higher pressures were also generated in smaller vertebrae based on a power relationship (r2 = 0.71 intact, r2 = 0.43 tumor).



Percutaneous vertebroplasty produces higher intravertebral pressures in vertebrae containing a simulated lytic metastasis than in intact vertebrae. Pressures generated in the tumor specimens are sufficiently elevated to cause embolic phenomena.




Osteoporosis - Comparison of Treatment Options

Compare EZorb Calcium with Osteoporosis Prescription Drugs

Bone and Joint Overview

Clinical Studies

The Importance of Collagen for Bone and Joint Health

Causes of Osteoarthritis

Treatment of Osteoarthritis - Review of Various Options

Is Rheumatoid Arthritis (RA) Really an Autoimmune Disease?

Breaking the Vicious Circle of Fibromyalgia

Bone Spur - A Natural Approach

Do You Suffer from Heel Spurs?

Juvenile Rheumatoid Arthritis

Quick EZorb Calcium Osteoporosis Facts


Ready to order? Go directly to our online store, or call 1-800-395-5715. Open 24 hours a day, 7 days a week. You may also use the mail order form to mail us your order.





Copyright © 2020 Elixir Industry. All Rights Reserved.